Health Conditions

Our Focus on Ischemic Disease Affecting Multiple Organs in the Body

Areas of Investigation

We're researching health conditions to help you.  Below is medical information about health conditions. You will also find links to active clinical trials as they come available. 

  • Angina (including Refractory Angina): Chest pain or discomfort due to reduced blood flow to the heart muscle, often from coronary artery disease; refractory cases persist despite standard treatments, limiting activity and quality of life.

  • Chronic Limb Threatening Ischemia (CLTI): A severe, advanced stage of peripheral artery disease with critical blockages in leg arteries, causing rest pain, non-healing ulcers, gangrene, and high amputation risk in no-option patients.

  • Congestive Heart Failure: A chronic condition where the heart cannot pump blood effectively, leading to fluid buildup, shortness of breath, swelling, fatigue, and reduced organ function.

  • Diabetic Foot (including Diabetic Foot Ulcers): Non-healing wounds or ulcers on the feet in people with diabetes, often due to poor circulation (ischemia), neuropathy, and infection; high risk of amputation if untreated.

  • Ehlers-Danlos Syndrome (EDS): A group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, fragility, chronic pain, and in some subtypes (e.g., vascular EDS), fragile blood vessels prone to rupture or complications; potential relevance to ACP-01 via vascular/ischemic aspects, though not a confirmed study indication.

  • Ischemic Cardiomyopathy: Heart muscle damage and weakening from prolonged reduced blood supply (e.g., prior heart attacks or blocked arteries), resulting in enlarged heart, poor pumping, and heart failure symptoms.

  • Neuropathic Pain (in ischemic or peripheral contexts): Chronic nerve pain from damaged nerves, often linked to ischemia or total body reduced circulation; causes burning, shooting pain, numbness, and reduced quality of life.

  • Non-Ischemic Dilated Cardiomyopathy: Enlargement and weakening of the heart's pumping chambers without coronary artery blockage as the primary cause (e.g., from viruses, toxins, or genetics), leading to inefficient heart function and heart failure.

  • Peripheral Arterial Disease (PAD): Narrowing of arteries (usually in the legs) from plaque buildup, reducing blood flow and causing leg pain during activity (claudication), poor healing, and higher cardiovascular risks.

  • Vascular Dementia: Cognitive decline from impaired brain blood flow due to strokes, small vessel disease, or other vascular issues, affecting memory, reasoning, planning, and daily functioning (often in a stepwise progression).

For a more comprehensive list of studies please visit www.clinicaltrials.gov